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GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice

Friday, September 4, 2009

Risbrough, Victoria B.; Brodkin, Jesse D.; Geyer, Mark A.
 
The present experiments characterized the acquisition of fear-potentiated startle and determined the sensitivity of FPS to anxiolytic compounds in DBA/1J mice. A light conditioned stimulus and mild footshock unconditioned stimulus were used. Startle chambers (SR-LAB, San Diego Instruments) consisted of nonrestrictive Plexiglass cylinders 5 cm in diameter resting on a Plexiglass platform in a ventilated chamber. High frequency speakers mounted above the cylinders produced all acoustic stimuli. Scrambled, constant-current footshocks were delivered through a cradle-shaped grid on the floor of the cylinder. Footshocks, startle intensities and light presentations were controlled by HSR2000 software (SR-LAB). Piezoelectric accelerometers mounted under the cylinders transduced movements of the animal, which were digitized and stored by interface and computer assembly.
 
For more information on this study, please refer to:
 
Neuropsychopharmacology

Vol 28(4), Apr 2003, 654-663.


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